Investigating how microglia contribute to neurodegeneration in Alzheimer's disease
Role of Microglia in Neurodegeneration -Effect of ApoE
This study is looking at how certain brain cells called microglia behave when they encounter misfolded proteins, which can lead to Alzheimer's disease, especially in people with a specific genetic risk factor, to help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11052501 on NIH RePORTER |
What this research studies
This research explores the role of microglia, a type of immune cell in the brain, in the development of neurodegenerative diseases like Alzheimer's. It uses mouse models to study how misfolded proteins affect microglial behavior and contribute to neurodegeneration. The research focuses on the impact of the APOE ε4 allele, a genetic risk factor for Alzheimer's, on microglial function and inflammation. By understanding these mechanisms, the study aims to uncover potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those carrying the APOE ε4 allele.
Not a fit: Patients with neurodegenerative diseases unrelated to Alzheimer's or those without genetic risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Sadowski, Martin Joseph — New York University School of Medicine
- Study coordinator: Sadowski, Martin Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.