Investigating how methionine and PI3K metabolism affect certain cancers linked to Epstein-Barr virus.
Methionine and PI3K Metabolism Drive CIMP in EBV Epithelial Cancers
This study is looking at how the Epstein-Barr virus affects certain types of cancers, like stomach and throat cancer, to find new ways to treat them by targeting specific changes in the cancer cells.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11085167 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Epstein-Barr virus (EBV) in epithelial cancers, particularly gastric cancer and nasopharyngeal carcinoma. It aims to explore how EBV interacts with tumor metabolism, specifically through the mechanisms of DNA methylation and PI3K signaling pathways. By utilizing advanced techniques like RNA sequencing and CRISPR/Cas9 gene editing, the study seeks to identify critical host factors that could be targeted to reverse cancer-promoting changes. The ultimate goal is to develop precision therapies that can effectively treat these cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gastric cancer or nasopharyngeal carcinoma associated with Epstein-Barr virus.
Not a fit: Patients with non-EBV-related cancers or those without epithelial cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with EBV-associated epithelial cancers.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in EBV-associated cancers, indicating potential for success in this approach.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Gewurz, Benjamin Elison — Wistar Institute
- Study coordinator: Gewurz, Benjamin Elison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.