Investigating how methamphetamine worsens brain inflammation in HIV patients
K channel, NLRP3 inflammasome and Meth exacerbation of HAND
This study is looking at how methamphetamine affects brain inflammation in people with HIV and how it might make thinking and memory problems worse, all while they are on treatment, to find ways to help improve their brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10663307 on NIH RePORTER |
What this research studies
This research explores the effects of methamphetamine on brain inflammation in individuals with HIV, particularly focusing on how it exacerbates neurocognitive disorders. The study aims to understand the mechanisms behind this worsening inflammation, especially in the context of ongoing antiretroviral therapy. By examining the role of specific immune cells and inflammatory markers, the research seeks to identify potential therapeutic targets that could mitigate these harmful effects. Patients may be involved in assessments that help clarify the relationship between drug use, inflammation, and cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who also use methamphetamine and are experiencing cognitive decline.
Not a fit: Patients who are not living with HIV or who do not use methamphetamine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for HIV-associated neurocognitive disorders, particularly for those affected by methamphetamine use.
How similar studies have performed: While there is ongoing research into HIV and neuroinflammation, the specific focus on methamphetamine's role in this context is relatively novel and underexplored.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Xiong, Huangui Hank — University of Nebraska Medical Center
- Study coordinator: Xiong, Huangui Hank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.