Investigating how methamphetamine affects HIV persistence and brain injury
Official title: Methamphetamine and Cysteinyl Leukotrienes in HIV Persistence
Funded at University of California Riverside · NIH-11170151 · Data updated 2026-11-12
This study is looking at how methamphetamine affects people living with HIV, especially how it might impact the virus and brain health, to find better ways to help those dealing with both HIV and drug use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $804,728 |
| NIH project number | 1R01DA063181-01 |
| Project ID | NIH-11170151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who also have a history of methamphetamine use.
✕Less likely to help
Patients who do not have HIV or a history of methamphetamine use may not benefit from this research.
What this research studies
This research explores the effects of methamphetamine on individuals living with HIV, particularly how it may influence the persistence of the virus and related brain injuries. The study employs advanced techniques, including single cell and single nuclei RNA sequencing, to understand the interactions between the drug and the virus at a cellular level. By examining the role of cysteinyl leukotrienes and their receptors, the research aims to uncover mechanisms that could lead to better treatment strategies for those affected by both HIV and substance use disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for managing HIV in patients who also use methamphetamine.
How similar studies have gone: While the interaction between methamphetamine and HIV persistence is not extensively studied, preliminary findings suggest that similar approaches may yield valuable insights.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Kaul, Marcus — University of California Riverside
- Study coordinator: Kaul, Marcus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.