Investigating how methamphetamine affects brain cell health and function
Methamphetamine, mitochondria, and neurodegeneration
This study looks at how long-term use of methamphetamine affects certain parts of the brain and the chemicals that help it work, with the goal of finding ways to protect brain health and prevent memory problems for people who have used this drug.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11013323 on NIH RePORTER |
What this research studies
This research explores the impact of chronic methamphetamine use on specific brain regions and neurotransmitter systems. It focuses on understanding how methamphetamine leads to degeneration of dopamine and norepinephrine neurons, particularly in the substantia nigra and locus coeruleus. The study employs advanced techniques to assess mitochondrial stress in axons, aiming to identify the mechanisms behind neurodegeneration. By examining the relationship between methamphetamine exposure and neuronal health, the research seeks to uncover potential therapeutic targets for preventing cognitive decline associated with substance use.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of methamphetamine use who are experiencing cognitive decline or related neurological symptoms.
Not a fit: Patients who have not used methamphetamine or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting brain health and improving cognitive function in individuals affected by methamphetamine use.
How similar studies have performed: Previous studies have shown promising results in understanding the neurotoxic effects of methamphetamine, suggesting that this research builds on established findings.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Graves, Steven Michael — University of Minnesota
- Study coordinator: Graves, Steven Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.