Investigating how metformin may influence aging mechanisms related to Alzheimer's disease risk
Official title: Targeting Biology of Aging Mechanisms Underlying Alzheimer's Disease Risk with Metformin
Funded at Cedars-Sinai Medical Center · NIH-10992073 · Data updated 2026-11-12
This study is looking at how a diabetes medication called metformin might help older adults by slowing down aging processes that could lead to Alzheimer's disease and related dementias, and it will compare its effects to a placebo to see if it can improve brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $828,960 |
| NIH project number | 1R01AG089711-01 |
| Project ID | NIH-10992073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above, particularly those who may be at risk for Alzheimer's disease or related dementias.
✕Less likely to help
Patients under the age of 65 or those without risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the connection between biological aging and the risk of Alzheimer's disease and related dementias (ADRD) in older adults. It aims to understand how metformin, a common diabetes medication, can potentially modify key aging pathways that contribute to the development of ADRD. By conducting a clinical trial, the researchers will compare the effects of metformin against a placebo in older adults, focusing on biological markers of aging and cognitive health. The study seeks to uncover whether targeting these aging mechanisms can help prevent or delay the onset of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease in older adults.
How similar studies have gone: Previous research has shown promising results in targeting aging mechanisms to improve health outcomes, suggesting that this approach may be viable.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Espinoza, Sara Elyse — Cedars-Sinai Medical Center
- Study coordinator: Espinoza, Sara Elyse
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.