Investigating how metastatic bone disease affects muscle loss in kidney cancer
Official title: Metastatic Bone Disease and IL-6 as Drivers of Cachexia in Kidney Cancer
Funded at Indiana University Indianapolis · NIH-11055003 · Data updated 2026-11-12
This study is looking at how kidney cancer that spreads to the bones can cause severe weight and muscle loss, and it aims to find ways to improve treatment for patients dealing with these tough symptoms.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | May 7, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $156,210 |
| NIH project number | 1K08AR082457-01A1 |
| Project ID | NIH-11055003 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with kidney cancer who are experiencing or at risk of cachexia.
✕Less likely to help
Patients with kidney cancer who do not exhibit symptoms of cachexia or metastatic bone disease may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between metastatic bone disease and cachexia, a condition characterized by severe muscle and weight loss, in patients with kidney cancer. The principal investigator, Dr. Christopher Collier, will utilize a mouse model to explore how metastatic bone disease contributes to cachexia and identify the biological factors involved. The study aims to bridge laboratory findings with clinical applications, ultimately enhancing treatment strategies for affected patients. By examining these connections, the research seeks to provide insights that could lead to improved management of kidney cancer and its debilitating effects.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that mitigate muscle loss and improve quality of life for kidney cancer patients.
How similar studies have gone: Previous research has shown promising results in understanding cachexia in cancer patients, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Collier, Christopher David — Indiana University Indianapolis
- Study coordinator: Collier, Christopher David
Related research
Other NIH-funded projects on the same topics.
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Mitochondrial pores and muscle loss in cancer cachexia
A small US-based study will explore how changes in mitochondria contribute to muscle wasting in people with cancer cachexia and how this may be slowed.
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CANCAN: A Virtual Institute to Cure Cancer Cachexia
A broad, collaborative NIH initiative aims to uncover why cancer patients lose weight and muscle and to develop new ways to treat this serious condition.
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Adipose tissue and its role in lung cancer cachexia
A new NIH grant explores how fat tissue around the body may feed lung cancer growth and drive weight loss, with the aim of finding ways to help patients who struggle with cancer cachexia.
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Maximizing anti-tumor immune responses in kidney cancer
A cutting-edge program at UT Southwestern aims to speed up better immunotherapy options for kidney cancer by studying how to activate both innate and adaptive immune responses.
-
Spatial metabolism mapping in cancer cachexia tissues
Aims to map where and how metabolism changes in tissues affected by cancer cachexia using advanced imaging technology.
-
Innate inflammatory control of cachexia in chronic disease
A research team is studying how inflammation drives cachexia in chronic disease using a parasite model to find therapies that could protect lean body mass without raising infection risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.