Investigating how metastatic bone disease affects muscle loss in kidney cancer
Metastatic Bone Disease and IL-6 as Drivers of Cachexia in Kidney Cancer
This study is looking at how kidney cancer that spreads to the bones can cause severe weight and muscle loss, and it aims to find ways to improve treatment for patients dealing with these tough symptoms.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11055003 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between metastatic bone disease and cachexia, a condition characterized by severe muscle and weight loss, in patients with kidney cancer. The principal investigator, Dr. Christopher Collier, will utilize a mouse model to explore how metastatic bone disease contributes to cachexia and identify the biological factors involved. The study aims to bridge laboratory findings with clinical applications, ultimately enhancing treatment strategies for affected patients. By examining these connections, the research seeks to provide insights that could lead to improved management of kidney cancer and its debilitating effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with kidney cancer who are experiencing or at risk of cachexia.
Not a fit: Patients with kidney cancer who do not exhibit symptoms of cachexia or metastatic bone disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that mitigate muscle loss and improve quality of life for kidney cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding cachexia in cancer patients, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Collier, Christopher David — Indiana University Indianapolis
- Study coordinator: Collier, Christopher David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.