Investigating how metal interactions affect a brain protein linked to Parkinson's disease
Alpha-Synuclein Assemblies and Metal-Mediated Redox Mechanisms
This study is looking at how metals like copper and iron interact with a protein called alpha-synuclein, which is important for understanding Parkinson's disease, and it hopes to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10688195 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between the protein alpha-synuclein and metals like copper and iron, which are believed to play a role in Parkinson's disease. By examining how these metals influence the structure and function of alpha-synuclein, the study aims to clarify the protein's behavior in the brain and its potential link to neurodegenerative disorders. The research employs biochemical techniques to analyze different conformations of the protein and their implications for disease progression. Patients may benefit from insights gained about the underlying mechanisms of Parkinson's disease, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk due to genetic or environmental factors.
Not a fit: Patients with neurodegenerative diseases unrelated to alpha-synuclein or metal interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with Parkinson's disease.
How similar studies have performed: Previous research has shown promising results in understanding protein-metal interactions in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Lucas, Heather R — Virginia Commonwealth University
- Study coordinator: Lucas, Heather R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.