Investigating how metal enzymes work in the body
Spectroscopic Investigations of Metalloenzyme Mechanisms
This study is exploring how certain important enzymes in our bodies work, especially those that contain metals and organic radicals, to help us understand their roles in health and how they carry out vital reactions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10863811 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms of enzymes that contain metal centers and organic radicals, which are essential for various biochemical processes in human health. Using advanced techniques like electron paramagnetic resonance (EPR) spectroscopy, the team aims to uncover how these enzymes are assembled and how they function in catalyzing important reactions. By studying specific enzymes, such as the [Fe-Fe] hydrogenase and nitrogenase, the research seeks to reveal the intricate processes that allow these enzymes to operate safely and effectively in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to enzyme deficiencies or metabolic disorders.
Not a fit: Patients with conditions unrelated to enzyme function or those not experiencing any biochemical disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into enzyme functions that may improve treatments for diseases linked to enzyme deficiencies.
How similar studies have performed: Other research has shown success in understanding enzyme mechanisms using spectroscopic techniques, indicating that this approach is promising.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Britt, R David — University of California at Davis
- Study coordinator: Britt, R David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.