Investigating how metal complexes activate oxygen for various biological processes
Official title: Heme and Nonheme Transition Metal Complexes, Reactivity, and Mechanism
Funded at Johns Hopkins University · NIH-10907410 · Data updated 2026-11-12
This study is looking at how certain metal compounds help activate oxygen, which is important for many biological processes, and it aims to uncover how this knowledge could lead to better understanding and treatments for diseases like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $577,001 |
| NIH project number | 5R35GM149233-02 |
| Project ID | NIH-10907410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by conditions related to enzyme dysfunctions, such as certain cancers or degenerative neurologic disorders.
✕Less likely to help
Patients with conditions unrelated to the biochemical processes involving heme and nonheme metal complexes may not benefit from this research.
What this research studies
This research explores the role of heme and nonheme transition metal complexes in activating dioxygen, which is crucial for various biological reactions. By studying metalloenzymes and synthetic systems, the project aims to understand how these metal centers mediate the oxidation of different substrates, including those involved in diseases like cancer and degenerative neurologic disorders. The research involves synthesizing biomimetic metal complexes to examine their interactions with oxygen and how they influence biological processes. Patients may benefit from insights gained into the mechanisms of diseases related to these enzymes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like cancer and degenerative neurologic disorders.
How similar studies have gone: Other research has shown promising results in understanding the mechanisms of similar metal complexes in biological systems, indicating a potential for success in this area.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Goldberg, David P — Johns Hopkins University
- Study coordinator: Goldberg, David P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.