Investigating how metabolites in different environments affect cancer spread
Project 3: The role of microenvironmental metabolites on metastatic progression
This study is looking at how breast cancer cells change their behavior to survive and grow in different parts of the body, especially in places where they don’t get enough nutrients and oxygen, to help us understand how to better fight the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10909183 on NIH RePORTER |
What this research studies
This research explores how the metabolic environment of distant organs influences the progression of breast cancer metastasis. It focuses on understanding how cancer cells adapt their metabolism to survive and grow in these challenging environments, which often lack essential nutrients and oxygen. By examining the interactions between cancer cells and their surroundings, the study aims to uncover the mechanisms that allow tumor cells to thrive in new locations. The research employs advanced techniques, including CRISPR, to manipulate and analyze these metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic breast cancer who may benefit from novel therapeutic approaches.
Not a fit: Patients with early-stage breast cancer or those not experiencing metastasis may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating metastatic breast cancer by targeting the metabolic adaptations of cancer cells.
How similar studies have performed: Other research has shown promising results in understanding cancer metabolism, suggesting that this approach could yield significant insights into metastatic processes.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Birsoy, Kivanc — Rockefeller University
- Study coordinator: Birsoy, Kivanc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.