Investigating how metabolism affects stomach shape and birth defects
Official title: Fueling left-right asymmetry: the role of glycolysis in stomach curvature
Funded at North Carolina State University Raleigh · NIH-10746142 · Data updated 2026-11-12
This study is looking at how the way our bodies process energy affects the shape and growth of the stomach during development, which is important for preventing certain birth defects that can cause organs to be arranged incorrectly.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $186,318 |
| NIH project number | 5R21HD111145-02 |
| Project ID | NIH-10746142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital anatomical abnormalities or birth defects that affect organ asymmetry.
✕Less likely to help
Patients with conditions unrelated to congenital defects or organ asymmetry may not benefit from this research.
What this research studies
This research focuses on understanding how differences in metabolism, specifically glycolysis, contribute to the left-right asymmetry of the stomach, which is crucial for normal organ development. The study examines how these metabolic processes influence the growth and shape of the stomach during embryonic development, particularly in the context of congenital abnormalities like heterotaxy. By analyzing the molecular and cellular mechanisms involved, the research aims to uncover new insights that could lead to better prevention or treatment strategies for related birth defects.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for congenital defects related to organ asymmetry.
How similar studies have gone: While the specific approach of linking glycolysis to organ asymmetry is novel, similar studies have shown success in understanding metabolic influences on organ development.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Nascone-Yoder, Nanette M — North Carolina State University Raleigh
- Study coordinator: Nascone-Yoder, Nanette M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.