Investigating how metabolism affects stomach shape and birth defects
Fueling left-right asymmetry: the role of glycolysis in stomach curvature
['FUNDING_R21'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10746142
This study is looking at how the way our bodies process energy affects the shape and growth of the stomach during development, which is important for preventing certain birth defects that can cause organs to be arranged incorrectly.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10746142 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how differences in metabolism, specifically glycolysis, contribute to the left-right asymmetry of the stomach, which is crucial for normal organ development. The study examines how these metabolic processes influence the growth and shape of the stomach during embryonic development, particularly in the context of congenital abnormalities like heterotaxy. By analyzing the molecular and cellular mechanisms involved, the research aims to uncover new insights that could lead to better prevention or treatment strategies for related birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital anatomical abnormalities or birth defects that affect organ asymmetry.
Not a fit: Patients with conditions unrelated to congenital defects or organ asymmetry may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for congenital defects related to organ asymmetry.
How similar studies have performed: While the specific approach of linking glycolysis to organ asymmetry is novel, similar studies have shown success in understanding metabolic influences on organ development.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NASCONE-YODER, NANETTE M — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: NASCONE-YODER, NANETTE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.