Investigating how metabolic stress contributes to liver cancer development
Official title: Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-10935863 · Data updated 2026-11-12
This study is looking at how extra weight and changes in metabolism might affect the growth of liver cancer in people with fatty liver disease, and it aims to find ways to slow down or prevent this cancer from getting worse.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,397,277 |
| NIH project number | 1P01CA281819-01A1 |
| Project ID | NIH-10935863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis (NASH) who are at risk for developing liver cancer.
✕Less likely to help
Patients without NASH or those with other types of liver disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of metabolic stress and hypernutrition in the progression of liver cancer, specifically hepatocellular carcinoma (HCC) driven by non-alcoholic steatohepatitis (NASH). The team will explore how changes in metabolism affect cancer development by studying specific cellular pathways and interactions. They aim to identify key components that could be targeted to slow down or prevent the progression of HCC. By using advanced techniques, including lineage tracing, they will investigate the mechanisms that drive these changes in liver cells.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver cancer in patients with NASH.
How similar studies have gone: Previous research has shown promising results in understanding metabolic pathways related to liver cancer, indicating that this approach has potential for success.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Kaufman, Randal J. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Kaufman, Randal J.
Related research
Other NIH-funded projects on the same topics.
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Role of metabolic stress in NASH-related liver cancer
This grant explores how metabolic stress linked to NASH may drive liver cancer and looks for ways to interrupt that process to help patients.
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How overeating and metabolic stress drive NASH-related liver cancer
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Neoadjuvant Immunotherapy Platform for Hepatocellular Carcinoma
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Testing a pig model for liver cancer treatments
This study is testing a special type of pig that has been genetically modified to develop liver cancer like humans do, to help find better treatments for people with liver cancer by seeing how different genetic changes respond to targeted therapies.
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Using advanced imaging to better understand liver cancer
This study is looking at new ways to spot and treat liver cancer using advanced imaging techniques, which could help doctors understand your cancer better and find the best treatment just for you.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.