Investigating how metabolic stress contributes to liver cancer development
Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)
This study is looking at how extra weight and changes in metabolism might affect the growth of liver cancer in people with fatty liver disease, and it aims to find ways to slow down or prevent this cancer from getting worse.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10935863 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of metabolic stress and hypernutrition in the progression of liver cancer, specifically hepatocellular carcinoma (HCC) driven by non-alcoholic steatohepatitis (NASH). The team will explore how changes in metabolism affect cancer development by studying specific cellular pathways and interactions. They aim to identify key components that could be targeted to slow down or prevent the progression of HCC. By using advanced techniques, including lineage tracing, they will investigate the mechanisms that drive these changes in liver cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis (NASH) who are at risk for developing liver cancer.
Not a fit: Patients without NASH or those with other types of liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver cancer in patients with NASH.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways related to liver cancer, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Kaufman, Randal J. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Kaufman, Randal J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.