Investigating how metabolic processes affect blood vessel inflammation and related diseases
Acetate and Endothelial Pathobiology
This study is looking at how certain metabolic processes affect a change in blood vessel cells that can lead to heart and lung diseases, and it hopes to find new ways to treat these conditions without causing unwanted side effects, which could help patients with issues like atherosclerosis and pulmonary arterial hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11077241 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of metabolic processes, particularly acetylation, in controlling endothelial-to-mesenchymal transition (EndMT), which is a key factor in chronic vascular inflammation and diseases like atherosclerosis and pulmonary arterial hypertension. The researchers aim to identify new therapeutic targets that can effectively inhibit EndMT without the side effects associated with systemic TGFβ signaling inhibition. By exploring the metabolic control of EndMT, the study seeks to develop targeted treatments that could lead to significant regression of atherosclerotic lesions and prevention of new ones. Patients may benefit from insights that could lead to innovative therapies for cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atherosclerosis, pulmonary arterial hypertension, or other related vascular inflammatory conditions.
Not a fit: Patients with non-vascular related conditions or those without chronic inflammation may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the progression of atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways to influence vascular inflammation, suggesting potential for success in this novel approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Arany, Zoltan P — University of Pennsylvania
- Study coordinator: Arany, Zoltan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.