Investigating how metabolic inflammation affects breast cancer in women with diabetes
Multiscale analysis of metabolic inflammation as a driver of breast cancer
['FUNDING_U01'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-10909116
This study is looking at how Type 2 diabetes might affect the way breast cancer grows and behaves in women, especially those with a specific type of cancer, to help find better treatments for them.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10909116 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the relationship between metabolic inflammation and breast cancer in women who also have Type 2 diabetes. It aims to identify specific metabolic and immune networks that contribute to tumor aggressiveness by using advanced modeling techniques and patient-derived tumor organoid experiments. By integrating various biological data, the study seeks to uncover how diabetes alters cancer progression, particularly in estrogen receptor-negative breast cancer, which is common among vulnerable patient populations. The findings could lead to more effective treatment strategies tailored for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with breast cancer who also have Type 2 diabetes, particularly those from underserved populations.
Not a fit: Patients without breast cancer or those who do not have Type 2 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and treatment options for women with breast cancer and Type 2 diabetes.
How similar studies have performed: Previous research has indicated that metabolic factors can significantly influence cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENIS, GERALD V — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: DENIS, GERALD V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus