Investigating how metabolic changes in specific cells affect muscle health in older adults
Official title: Fibro/Adipogenic Progenitor Metabolic Reprogramming for Age-Related Muscle Fibrosis
Funded at Duke University · NIH-10936688 · Data updated 2026-11-12
This study is looking at how certain cells in our muscles can lead to stiffness and problems with movement as we get older, and it aims to find ways to help keep our muscles healthy and flexible.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $116,710 |
| NIH project number | 1K01AG088232-01 |
| Project ID | NIH-10936688 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be experiencing muscle-related issues or decreased mobility.
✕Less likely to help
Patients under the age of 65 or those without muscle fibrosis or related mobility issues may not benefit from this research.
What this research studies
This research focuses on understanding how fibro/adipogenic progenitor cells (FAPs) contribute to muscle fibrosis, particularly in older adults. The project aims to enhance the knowledge of muscle cell biology and metabolism through advanced techniques like mass spectrometry and computational analysis of metabolomics data. By manipulating metabolic pathways in these cells, the research seeks to find ways to counteract muscle fibrosis, which can lead to decreased mobility in aging populations. The principal investigator, Dr. David Lee, will receive mentorship and training to develop an independent research program that fosters collaboration and inclusivity in scientific exploration.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating muscle fibrosis, improving mobility and quality of life for older adults.
How similar studies have gone: Previous research has shown promising results in understanding muscle biology and metabolic interventions, suggesting that this approach could yield significant insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Lee, David E. — Duke University
- Study coordinator: Lee, David E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.