Investigating how metabolic changes affect wound healing in diabetic veterans
Official title: Metabolic Immunomodulation of Wound-Associated Macrophage Functional Plasticity as a Novel Diagnostic Target in Diabetic Veterans
Funded at Boise VA Medical Center · NIH-11098487 · Data updated 2026-11-12
This study is looking at how diabetes affects wound healing in veterans, especially those at risk of losing a limb, by exploring how certain immune cells work in the healing process and finding ways to better predict and improve their recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boise VA Medical Center NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005344-04 |
| Project ID | NIH-11098487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are military veterans with diabetes who are experiencing or at risk for diabetic ulcers.
✕Less likely to help
Patients without diabetes or those who do not have wounds related to diabetes may not benefit from this research.
What this research studies
This research focuses on understanding how metabolic factors influence the healing of wounds in diabetic veterans, particularly those who may be at risk for lower limb amputations. The study examines the role of macrophages, a type of immune cell, in the healing process and how their function changes in the presence of diabetes. By analyzing the metabolic environment of wounds, researchers aim to identify potential biomarkers that could help predict healing outcomes and improve treatment strategies for veterans with diabetic ulcers.
Why it matters
Potential benefit: If successful, this research could lead to improved healing strategies for diabetic veterans, potentially reducing the incidence of amputations and enhancing their quality of life.
How similar studies have gone: Previous research has shown that understanding the immune response in wound healing can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
-
Boise VA Medical Center
Boise, United States Active
Researchers
- Principal investigator: Ammons, Mary Cloud Bosworth — Boise VA Medical Center
- Study coordinator: Ammons, Mary Cloud Bosworth
Related research
Other NIH-funded projects on the same topics.
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Diabetic Foot Ulcer Healing Network at the University of Arizona
A NIH-supported project at the University of Arizona aims to improve healing of diabetic foot ulcers by studying biomarkers and running high-quality clinical trials.
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Understanding how skin layers coordinate healing after injury
Researchers are studying how different layers of adult skin coordinate rapid healing after injury to prevent infection and chronic wounds.
-
Immunomodulatory therapy to speed up healing after oral cavity injuries in kids
A new approach using a drug called FTY720 aims to improve healing and reduce pain after oral injuries or palate surgery in children.
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How diabetic wounds let Group B Streptococcus cause infections
Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.
-
Understanding how skin cells exchange harmful chemicals to cause injury and wound repair
A research project aims to uncover how certain chemical agents damage human skin and what happens in the early stages of blistering and inflammation.
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Intestinal mucosal wound healing in humans
A patient-friendly look at how the lining of the gut repairs itself after injury and why this matters for conditions like inflammatory bowel disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.