Investigating how metabolic changes affect lung blood vessel disease in children with heart defects
Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease
This study is looking at how changes in the body's metabolism can affect lung blood vessels in kids with congenital heart disease, hoping to find new ways to help improve their health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10922689 on NIH RePORTER |
What this research studies
This research focuses on understanding pulmonary vascular disease (PVD) in children with congenital heart disease (CHD), which can lead to increased blood flow and pressure in the lungs. The study examines how metabolic reprogramming in the body contributes to early injury and disease in the pulmonary vasculature. Using a lamb model, researchers will analyze changes in blood vessel structure and function, aiming to uncover the mechanisms behind these adaptations and their implications for treatment. By exploring the relationship between metabolism and vascular health, the research seeks to identify potential therapeutic targets for improving outcomes in affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old diagnosed with congenital heart disease, particularly those experiencing pulmonary vascular disease.
Not a fit: Patients with congenital heart disease who do not exhibit pulmonary vascular disease or are over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung health and overall outcomes for children with congenital heart disease.
How similar studies have performed: Previous research has shown promising results in understanding metabolic changes in vascular diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: Black, Stephen M — Florida International University
- Study coordinator: Black, Stephen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.