Investigating how mesenchymal cell environments affect treatment in triple negative breast cancer

Who could benefit from this research

What this research studies

This research focuses on understanding the role of mesenchymal cells in the growth and treatment response of triple negative breast cancer (TNBC) by examining the Hedgehog (Hh) signaling pathway. Researchers aim to develop in vitro models that mimic the tumor environment to identify how different types of mesenchymal cells influence the effectiveness of Hh inhibitors. By studying these interactions, the research seeks to uncover new therapeutic targets and improve treatment outcomes for patients with TNBC.

Why it matters

Where this research is happening

• University of Puerto Rico Mayaguez
  Mayaguez, United States Active

Researchers

• Principal investigator: Domenech, Maribella — University of Puerto Rico Mayaguez
• Study coordinator: Domenech, Maribella

Related research

Other NIH-funded projects on the same topics.

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• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

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  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

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  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.