Investigating how mesenchymal cell environments affect treatment in triple negative breast cancer
Distinct contributions of mesenchymal cell niches in the therapeutic potential of the hedgehog pathway in triple negative breast cancer
This study is looking at how certain cells in the body affect the growth of triple negative breast cancer and how well treatments work, with the goal of finding better ways to help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Mayaguez NIH-funded |
| Lab location | 1 site (Mayaguez, United States) |
| Project ID | NIH-10666446 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mesenchymal cells in the growth and treatment response of triple negative breast cancer (TNBC) by examining the Hedgehog (Hh) signaling pathway. Researchers aim to develop in vitro models that mimic the tumor environment to identify how different types of mesenchymal cells influence the effectiveness of Hh inhibitors. By studying these interactions, the research seeks to uncover new therapeutic targets and improve treatment outcomes for patients with TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple negative breast cancer who may benefit from targeted therapies.
Not a fit: Patients with non-triple negative breast cancer or those who are not eligible for Hh inhibitor treatments may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for patients with triple negative breast cancer.
How similar studies have performed: Other research has shown promising results in targeting the Hedgehog signaling pathway in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Mayaguez, United States
- University of Puerto Rico Mayaguez — Mayaguez, United States (Active)
Researchers
- Principal investigator: Domenech, Maribella — University of Puerto Rico Mayaguez
- Study coordinator: Domenech, Maribella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.