Investigating how Mertk helps regenerate alveolar bone after tooth loss
Official title: Mertk-driven regeneration of alveolar bone
Funded at University of Michigan at Ann Arbor · NIH-11100396 · Data updated 2026-11-12
This study is looking at how a protein called Mertk helps heal and regenerate the bone in your mouth after losing a tooth, which could lead to better treatments for people with missing teeth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 9, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $476,287 |
| NIH project number | 1R01DE034695-01 |
| Project ID | NIH-11100396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing partial or complete tooth loss who are seeking options for bone regeneration.
✕Less likely to help
Patients with intact dentition or those who do not require bone regeneration after tooth loss may not benefit from this research.
What this research studies
This research focuses on understanding how the Mertk protein influences the healing and regeneration of alveolar bone, which is crucial for maintaining oral function and aesthetics after tooth loss. The study will explore the role of Mertk in the healing process by examining its effects on bone stem cells and immune cell behavior in the area of bone loss. By utilizing both pharmacological and genetic approaches, the research aims to uncover the mechanisms that enhance bone regeneration, potentially leading to improved treatment options for patients with missing teeth.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve bone regeneration after tooth extraction, enhancing patients' quality of life.
How similar studies have gone: Previous studies have shown promising results in enhancing bone regeneration through targeted approaches, suggesting that this research could build on established findings.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Decker, Ann Marie — University of Michigan at Ann Arbor
- Study coordinator: Decker, Ann Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.