Investigating how menstrual cycle symptoms relate to lung disease in women with LAM
Official title: Menstrual Cycle-Related Symptom Variability as a Prognostic Indicator in Lymphangioleiomyomatosis
Funded at University of Cincinnati · NIH-10669246 · Data updated 2026-11-12
This study is looking at how changes in menstrual cycle symptoms might help doctors understand the health of women with Lymphangioleiomyomatosis (LAM) and figure out who might benefit from hormone treatments, so they can offer more personalized care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $202,500 |
| NIH project number | 5R21TR003858-02 |
| Project ID | NIH-10669246 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premenopausal women diagnosed with Lymphangioleiomyomatosis who experience variability in menstrual cycle-related symptoms.
✕Less likely to help
Patients who are postmenopausal or those who do not have Lymphangioleiomyomatosis may not benefit from this research.
What this research studies
This research focuses on understanding how variations in menstrual cycle-related symptoms can serve as indicators for the prognosis of Lymphangioleiomyomatosis (LAM), a rare lung disease that predominantly affects women. The study aims to identify which patients may benefit from hormonal therapies by analyzing their symptoms in relation to their lung function and overall health. By gathering data through surveys and clinical assessments, the research seeks to provide insights that could lead to more personalized treatment options for women suffering from LAM.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for women with LAM, potentially enhancing their quality of life and lung function.
How similar studies have gone: Previous studies have indicated the importance of hormonal influences in LAM, but this specific approach to identifying patient subsets for hormonal therapy is novel.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Gupta, Nishant — University of Cincinnati
- Study coordinator: Gupta, Nishant
Related research
Other NIH-funded projects on the same topics.
-
Social media, mood, and teens: how the menstrual cycle affects rejection feelings and online experiences
Teenagers using social media may feel stronger negative reactions to online feedback, especially around certain times in their menstrual cycle, which could relate to mood and depression.
-
How menstrual-cycle hormones affect ADHD and thinking
This project is looking at whether monthly hormone changes during the menstrual cycle change ADHD symptoms and cognitive function in adolescent and adult women.
-
How climate and air pollution relate to menstrual health and PCOS risk
This project looks at whether temperature, humidity, and air pollution across a person’s life affect menstrual cycles and the chance of developing PCOS in people of different racial and ethnic groups.
-
Effects of ovarian hormones on mood and sleep in adolescent girls
This study is looking at how changes in hormone levels during the menstrual cycle can affect mood and sleep in girls aged 11-14, to help understand why some may experience more sadness or sleep problems during this time.
-
Understanding suicide risk in adolescent girls during their menstrual cycle
This study is looking at how different stages of the menstrual cycle might influence suicidal thoughts and feelings in teenage girls, so we can better understand when they might be at greater risk and help support their mental health.
-
How climate and racial factors affect menstrual health
This study is looking at how things like climate and air pollution might affect your menstrual cycle and the risk of conditions like PCOS, especially for different racial and ethnic groups, to help understand how these factors impact reproductive health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.