Investigating how membrane proteins and lipids interact in cells
Understanding organization of membrane proteins and lipids through lipid vesicle native mass spectrometry
This study is exploring how proteins in our cells interact with fats, which is important for keeping our cells healthy, and it's using a new method to get a clearer picture of these interactions to help us understand more about how our bodies work and what can go wrong in diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11078748 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between membrane proteins and lipids, which are crucial for cellular function. By developing a new experimental platform that combines lipid vesicle technologies with native mass spectrometry, the researchers aim to analyze protein complexes directly from lipid bilayers. This approach allows for a more accurate study of how these proteins respond to external stimuli, which is essential for understanding various biological processes and diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to membrane protein abnormalities, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to membrane protein interactions or those who do not have any cellular membrane-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cellular mechanisms and potentially inform the development of targeted therapies for diseases related to membrane protein dysfunction.
How similar studies have performed: While the approach of using native mass spectrometry for studying membrane proteins is innovative, similar methodologies have shown promise in other areas of biophysical research.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Gupta, Kallol — Yale University
- Study coordinator: Gupta, Kallol
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.