Investigating how membrane contact sites affect calcium dynamics and synaptic transmission in neurons
Official title: The Role of VAP Membrane Contact Sites in Axonal Calcium Dynamics and Synaptic Transmission
Funded at Dartmouth College · NIH-11068887 · Data updated 2026-11-12
This study is looking at how special connections in brain cells help control calcium levels and communication between neurons, which is important for brain health and function.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | December 2, 2024 |
| Project end | December 1, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS141318-01 |
| Project ID | NIH-11068887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological disorders that affect synaptic function, such as amyotrophic lateral sclerosis (ALS).
✕Less likely to help
Patients with purely psychiatric disorders or those without any neurological conditions may not receive benefit from this research.
What this research studies
This research explores the role of membrane contact sites (MCSs) in neurons, particularly how they influence calcium dynamics and synaptic transmission. By examining the interactions between the endoplasmic reticulum and other organelles, the study aims to understand how these contact sites contribute to the signaling processes that are crucial for neuron communication. The research utilizes advanced techniques, including optogenetic calcium indicators, to visualize and analyze calcium signaling in real-time during neuronal activity. This could provide insights into the fundamental mechanisms of synaptic function and neuronal health.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurological conditions by enhancing our understanding of synaptic transmission and calcium signaling.
How similar studies have gone: While the specific focus on VAP and MCSs in axonal signaling is relatively novel, similar approaches have shown promise in understanding calcium dynamics in other neuronal contexts.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Paton, Cameron D — Dartmouth College
- Study coordinator: Paton, Cameron D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.