Investigating how melusin affects heart muscle growth in response to stress
Mechanotransduction by Melusin in Cardiac Hypertrophy
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10653705
This study is looking at a protein called melusin in heart cells to see how it helps the heart respond to stress, which can cause the heart muscle to grow too much; the goal is to find new ways to help people with heart conditions related to this issue.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10653705 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of melusin, a protein in heart cells, in how these cells respond to increased stress, which can lead to heart muscle growth or hypertrophy. The study will explore the mechanisms by which melusin influences this process, using advanced techniques such as engineered heart tissue and transgenic mice. By examining how melusin interacts with other signaling pathways in heart cells, the research aims to uncover new insights into heart health and disease. Patients may benefit from findings that could lead to new treatments for various forms of heart disease related to hypertrophy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to cardiac hypertrophy, such as hypertrophic cardiomyopathy or dilated cardiomyopathy.
Not a fit: Patients with non-cardiac related conditions or those without any form of heart disease may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart conditions associated with abnormal muscle growth.
How similar studies have performed: Previous research has shown promising results in understanding mechanotransduction in heart cells, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SNIADECKI, NATHAN JOHN — UNIVERSITY OF WASHINGTON
- Study coordinator: SNIADECKI, NATHAN JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.