Investigating how mechanical signals affect abdominal aortic aneurysms
Targeting Biomechanical Signaling in AAA
['FUNDING_OTHER'] · RALPH H JOHNSON VA MEDICAL CENTER · NIH-11063132
This study is looking at how certain molecules can help us understand and treat abdominal aortic aneurysms (AAA) better, with the goal of finding new ways to slow down or stop the growth of this condition that affects many people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RALPH H JOHNSON VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11063132 on ClinicalTrials.gov |
What this research studies
This research focuses on abdominal aortic aneurysms (AAA), a condition affecting about 8% of Americans, which can lead to high mortality rates if ruptured. The study aims to develop a platform that incorporates patient-specific mechanical stress factors to improve treatment decisions for AAA. By exploring the effects of two signaling molecules, AT1R and SGK-1, the research seeks to understand their roles in AAA growth and potential therapeutic interventions. Pre-clinical experiments have shown promise in inhibiting AAA growth using specific blockers, which could lead to better management of this condition in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms, particularly those with small aneurysms who may benefit from new treatment options.
Not a fit: Patients who do not have abdominal aortic aneurysms or those with advanced AAA requiring immediate surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new medical therapies that significantly reduce the growth and rupture rates of abdominal aortic aneurysms.
How similar studies have performed: Previous research has shown success in targeting similar mechanical signaling pathways in pre-clinical models, suggesting a promising avenue for clinical application.
Where this research is happening
CHARLESTON, UNITED STATES
- RALPH H JOHNSON VA MEDICAL CENTER — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUDDY, JEAN MARIE — RALPH H JOHNSON VA MEDICAL CENTER
- Study coordinator: RUDDY, JEAN MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.