Investigating how matrix receptors affect chronic kidney disease
Matrix receptors in chronic kidney disease
This study is looking at how a specific protein called DDR1 affects kidney health in people with chronic kidney disease, hoping to find new ways to slow down the damage and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10454133 on NIH RePORTER |
What this research studies
This research focuses on chronic kidney disease (CKD), a condition characterized by the progressive loss of kidney function. The study examines the role of discoidin domain receptor 1 (DDR1), a matrix receptor that influences kidney cell behavior and contributes to kidney damage and fibrosis. By using a mouse model, the research aims to understand how DDR1 activation leads to inflammation and fibrosis in the kidneys, potentially identifying new therapeutic targets to slow or halt disease progression. Patients may benefit from insights gained about DDR1 and its role in CKD, which could lead to novel treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease or those at risk of developing it.
Not a fit: Patients with acute kidney injury that does not progress to chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow or stop the progression of chronic kidney disease.
How similar studies have performed: Previous research has shown that targeting matrix receptors like DDR1 can be beneficial in other fibrotic diseases, suggesting a promising avenue for CKD treatment.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Pozzi, Ambra — Vanderbilt University Medical Center
- Study coordinator: Pozzi, Ambra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.