Investigating how maternal antibodies affect HIV-1 transmission from mother to child
Antibody dependent cellular cytotoxicity and HIV-1 mother to child transmission
This study is looking at how a mother's antibodies can help protect her baby from getting HIV-1 during pregnancy, birth, and breastfeeding, and it aims to find out which specific antibodies are most helpful so we can improve ways to prevent the virus from passing from mother to child.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10890101 on NIH RePORTER |
What this research studies
This research explores the role of maternal antibodies in preventing the transmission of HIV-1 from infected mothers to their infants. It focuses on understanding how these antibodies function in natural settings where infants are exposed to the virus during pregnancy, birth, and breastfeeding. By studying mother-child pairs, the research aims to identify specific types of antibodies that may offer protection against HIV-1 transmission. This could provide valuable insights for developing effective vaccines and treatments for preventing mother-to-child transmission of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants born to HIV-1 infected mothers and their mothers who are willing to participate in the study.
Not a fit: Patients who are not at risk of HIV-1 transmission or those who are not mothers or infants will not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing HIV-1 transmission from mothers to infants, potentially saving thousands of lives.
How similar studies have performed: Previous research has shown that understanding maternal antibodies in similar contexts can lead to significant advancements in preventing HIV transmission, indicating a promising avenue for this investigation.
Where this research is happening
Boston, United States
- Boston Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Sagar, Manish — Boston Medical Center
- Study coordinator: Sagar, Manish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.