Investigating how mast cells contribute to lung injury from chemical threats
Official title: Mast Cell Activation as a Common Mechanism of Pulmonary Toxicity by Chemical Threat Agents
Funded at University of Colorado Denver · NIH-10887265 · Data updated 2026-11-12
This study is looking at how certain chemicals that can harm the lungs affect special immune cells called mast cells, with the goal of finding new ways to help protect or treat lung injuries caused by things like pollution or chemical exposure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 20, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $462,501 |
| NIH project number | 1R56ES034386-01A1 |
| Project ID | NIH-10887265 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to chemical agents or those with respiratory conditions exacerbated by environmental toxins.
✕Less likely to help
Patients with lung injuries not related to chemical exposures or those with chronic respiratory diseases unrelated to mast cell activation may not benefit from this research.
What this research studies
This research focuses on understanding how mast cells, a type of immune cell, are activated by various chemical agents that can cause lung injury. The study aims to identify common inflammatory mechanisms triggered by these agents, which include substances like nitrogen mustard and diesel exhaust. By examining how mast cells respond to these chemicals, the research seeks to uncover potential therapeutic targets and biomarkers that could help in treating or preventing lung damage from chemical exposures. Patients may benefit from insights gained about how to better protect against or treat lung injuries caused by environmental toxins.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive measures for lung injuries caused by chemical threats.
How similar studies have gone: Previous research has shown that mast cell activation plays a significant role in lung inflammation, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Brown, Jared Michael — University of Colorado Denver
- Study coordinator: Brown, Jared Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.