Investigating how mast cells affect heart tissue after a heart attack using advanced MRI techniques.
Assessment of Mast Cell Degranulation in Infarcted Myocardium Using Quantitative Multiparametric MRI
This study is looking at how certain cells in the heart react after a heart attack and testing a new medication that might help heal the heart better, so it can improve recovery for people who have had a heart attack.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10877149 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of mast cell degranulation in heart tissue following a myocardial infarction (heart attack). Using quantitative multiparametric magnetic resonance imaging (qMRI), the study aims to evaluate the effectiveness of a new pharmacological treatment that targets the damage caused by heart attacks. The approach involves assessing various biomarkers that indicate injury and inflammation in the heart, which could lead to better therapeutic strategies for patients recovering from heart attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction and are undergoing treatment.
Not a fit: Patients who have not experienced a heart attack or those with chronic heart conditions unrelated to recent myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce heart damage and enhance recovery after a heart attack.
How similar studies have performed: Previous research has shown promising results in using advanced imaging techniques to assess heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Li, Debiao — Cedars-Sinai Medical Center
- Study coordinator: Li, Debiao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.