Investigating how mast cell stabilization affects heart inflammation and glucose use in aging hearts after a heart attack
Official title: Multiparametric PET/MRI Assessment of Mast Cell Stabilization Effects on Inflammaging and Glucose Utilization in Infarcted Myocardium
Funded at Cedars-Sinai Medical Center · NIH-11062399 · Data updated 2026-11-12
This study is looking at how keeping certain cells in the heart stable might help reduce inflammation and improve how the heart uses sugar in older adults who have had a heart attack, using special imaging techniques to better understand heart health and metabolism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $751,427 |
| NIH project number | 5R01HL168635-03 |
| Project ID | NIH-11062399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have experienced a heart attack and are not diabetic.
✕Less likely to help
Patients who are younger or do not have a history of heart attacks may not benefit from this research.
What this research studies
This research focuses on understanding how mast cell stabilization can influence inflammation and glucose utilization in the hearts of older adults who have experienced a heart attack. By using advanced imaging techniques like PET/MRI, the study aims to assess the effects of fat accumulation in heart tissue and its relationship with insulin resistance. The research will involve both animal models and human participants to explore the underlying mechanisms of heart failure and metabolic changes in aging hearts. Patients may undergo imaging and assessments to evaluate their heart health and metabolic function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health and metabolic function in older adults, potentially reducing the risk of heart failure.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation and fat accumulation in heart disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Cokic, Ivan — Cedars-Sinai Medical Center
- Study coordinator: Cokic, Ivan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.