Investigating how MARCH proteins help fight HIV
MARCH Proteins, Members of a Host Protein Family that Targets HIV
This study is looking at special proteins that help our immune system fight HIV, and it aims to find new ways to improve treatments for people living with HIV by understanding how the virus tries to escape these proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10992150 on NIH RePORTER |
What this research studies
This research focuses on MARCH proteins, which play a crucial role in regulating immune responses against HIV. By studying how these proteins restrict HIV infection and understanding the mechanisms involved, the research aims to uncover new ways to enhance antiviral therapies. The project will explore how HIV may evade these proteins and how different strains of the virus respond to MARCH-mediated restrictions. Patients may benefit from insights that could lead to more effective treatments for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV or do not have risk factors for HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies that enhance the body's ability to fight HIV.
How similar studies have performed: Previous research has shown that targeting host proteins can effectively restrict viral infections, suggesting potential success for this approach.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Stavrou, Spyridon — State University of New York at Buffalo
- Study coordinator: Stavrou, Spyridon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.