Investigating how manganese exposure affects brain function and mood.
Neuroimaging of Manganese Toxicity
This study is looking at how breathing in manganese from welding fumes might affect brain health, especially in terms of mood, thinking skills, and movement, using special brain scans to see how manganese builds up in different areas of the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11012790 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of manganese exposure, particularly from welding fumes, on brain health. Using advanced magnetic resonance imaging (MRI) and spectroscopy (MRS), the study aims to map manganese accumulation in the brain and assess its relationship with mood, cognitive abilities, and motor functions. The research will explore how oxidative stress and neurotransmitter imbalances are linked to these changes, providing insights into the dose-response relationships of manganese in specific brain regions. By examining these factors, the study seeks to enhance our understanding of manganese toxicity in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are welders or individuals with known exposure to manganese fumes.
Not a fit: Patients who have no history of manganese exposure or neurological symptoms related to manganese toxicity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of manganese-related neurological issues in exposed individuals.
How similar studies have performed: While there have been studies on manganese toxicity in animals, this research employs novel human neuroimaging techniques, making it a unique approach.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Dydak, Ulrike — Purdue University
- Study coordinator: Dydak, Ulrike
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.