Investigating how manganese affects brain function and schizophrenia risk
Role of glycosylation in environmental and genetic schizophrenia risk
This study is looking at how manganese, a metal our bodies need, might affect brain development and function, especially in relation to the risk of schizophrenia, to help us understand how too much manganese can harm the brain in both kids and adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10994591 on NIH RePORTER |
What this research studies
This research explores the impact of manganese, an essential metal, on brain development and function, particularly in relation to schizophrenia risk. It focuses on understanding how elevated levels of manganese can lead to neurotoxicity and cognitive deficits in both children and adults. The study employs advanced genetic models to selectively increase manganese levels in specific types of neurons, allowing researchers to pinpoint the effects on brain function and the mechanisms of manganese homeostasis. By examining these processes, the research aims to uncover critical insights into the environmental and genetic factors contributing to schizophrenia.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to elevated levels of manganese, particularly those showing early signs of cognitive or motor deficits.
Not a fit: Patients who have not been exposed to manganese or do not exhibit any cognitive or motor deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for cognitive and motor deficits associated with manganese exposure and schizophrenia.
How similar studies have performed: Previous research has shown promising results in understanding the neurotoxic effects of manganese, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Taylor, Cherish a — Boston Children's Hospital
- Study coordinator: Taylor, Cherish a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.