Investigating how male factors affect fertility and pregnancy outcomes
Official title: A prospective study of male factors, fertility, and pregnancy outcomes
Funded at Boston University Medical Campus · NIH-11089499 · Data updated 2026-11-12
This study is exploring how things like lifestyle, diet, and health history affect men's fertility and pregnancy success, and it's inviting couples to share information and samples online to help uncover what really matters for male reproductive health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 5, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $663,115 |
| NIH project number | 5R01HD105863-05 |
| Project ID | NIH-11089499 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include couples experiencing difficulty conceiving, particularly those where male infertility is suspected.
✕Less likely to help
Patients who are not trying to conceive or those without male partners may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of male factors in fertility and pregnancy outcomes, particularly looking at how lifestyle, dietary habits, and medical history influence male fertility. The study involves recruiting couples to participate in a web-based preconception cohort, where male partners provide information and semen samples to assess their reproductive health. By analyzing data from over 3,000 male participants, the research aims to identify key determinants of male fertility and their impact on pregnancy success.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of male infertility, ultimately enhancing couples' chances of achieving pregnancy.
How similar studies have gone: Previous research has shown promising results in understanding male factors affecting fertility, indicating that this approach has potential for significant findings.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Wise, Lauren a — Boston University Medical Campus
- Study coordinator: Wise, Lauren a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.