Investigating how male and female proteins affect reproductive success in fruit flies.
Official title: Male x Female Protein Interactions Mediating Reproductive Success in the Drosophila Mating Plug
Funded at Cornell University · NIH-10991005 · Data updated 2026-11-12
This study looks at how male and female proteins in fruit flies work together during mating to help ensure successful reproduction, which could help us understand more about fertility and infertility in general.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $74,284 |
| NIH project number | 5F32HD111231-02 |
| Project ID | NIH-10991005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of reproduction and infertility.
✕Less likely to help
Patients who are not affected by infertility or who do not have an interest in reproductive biology may not benefit from this research.
What this research studies
This research explores the interactions between male and female proteins in fruit flies (Drosophila melanogaster) that contribute to reproductive success. By examining the formation and ejection of the mating plug, which is crucial for sperm retention, the study aims to identify genetic factors that influence these processes. The research employs genetic analysis and functional investigations to understand how variations in male and female proteins affect mating outcomes. This could provide insights into the biological mechanisms underlying fertility and infertility.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of reproductive biology and potentially inform treatments for infertility.
How similar studies have gone: While the specific focus on male x female protein interactions in Drosophila is relatively novel, similar studies in reproductive biology have shown promising results in understanding fertility mechanisms.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Carlisle, Jolie Anna — Cornell University
- Study coordinator: Carlisle, Jolie Anna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.