Investigating how magnetic stimulation affects brain cell activity based on their state
Cellular Mechanisms Underlying State-Dependent Neural Inhibition with Magnetic Stimulation
['FUNDING_R03'] · LOYOLA UNIVERSITY OF CHICAGO · NIH-10574102
This study is looking at how a special treatment called rTMS can work better for people with neurological conditions by understanding how individual brain cells respond to it, so we can tailor the treatment to fit each person's needs.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOYOLA UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10574102 on ClinicalTrials.gov |
What this research studies
This research explores how repetitive transcranial magnetic stimulation (rTMS) can modulate neural activity in the brain, particularly focusing on how the state of individual neurons influences the effectiveness of this treatment. By using advanced micro-coil technology, the study aims to achieve precise stimulation of single neurons, allowing researchers to observe how different levels of neuronal excitability affect responses to magnetic stimulation. This approach could lead to a better understanding of the cellular mechanisms involved in rTMS and improve treatment outcomes for neurological conditions. Patients may benefit from insights gained about optimizing rTMS parameters for their specific brain states.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from neurological conditions such as depression or epilepsy who are considering rTMS as a treatment option.
Not a fit: Patients with conditions unrelated to neurological function or those who do not respond to rTMS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of rTMS treatments for neurological disorders, potentially leading to better management of conditions like depression and epilepsy.
How similar studies have performed: While rTMS has shown clinical success in treating various neurological disorders, the specific investigation of state-dependent mechanisms at the cellular level is a novel approach.
Where this research is happening
CHICAGO, UNITED STATES
- LOYOLA UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YE, HUI — LOYOLA UNIVERSITY OF CHICAGO
- Study coordinator: YE, HUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.