Investigating how magnetic stimulation affects brain cell activity based on their state
Official title: Cellular Mechanisms Underlying State-Dependent Neural Inhibition with Magnetic Stimulation
Funded at Loyola University of Chicago · NIH-10574102 · Data updated 2026-11-12
This study is looking at how a special treatment called rTMS can work better for people with neurological conditions by understanding how individual brain cells respond to it, so we can tailor the treatment to fit each person's needs.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $145,453 |
| NIH project number | 1R03NS130387-01 |
| Project ID | NIH-10574102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from neurological conditions such as depression or epilepsy who are considering rTMS as a treatment option.
✕Less likely to help
Patients with conditions unrelated to neurological function or those who do not respond to rTMS may not benefit from this research.
What this research studies
This research explores how repetitive transcranial magnetic stimulation (rTMS) can modulate neural activity in the brain, particularly focusing on how the state of individual neurons influences the effectiveness of this treatment. By using advanced micro-coil technology, the study aims to achieve precise stimulation of single neurons, allowing researchers to observe how different levels of neuronal excitability affect responses to magnetic stimulation. This approach could lead to a better understanding of the cellular mechanisms involved in rTMS and improve treatment outcomes for neurological conditions. Patients may benefit from insights gained about optimizing rTMS parameters for their specific brain states.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of rTMS treatments for neurological disorders, potentially leading to better management of conditions like depression and epilepsy.
How similar studies have gone: While rTMS has shown clinical success in treating various neurological disorders, the specific investigation of state-dependent mechanisms at the cellular level is a novel approach.
Where this research is happening
-
Loyola University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Ye, Hui — Loyola University of Chicago
- Study coordinator: Ye, Hui
Related research
Other NIH-funded projects on the same topics.
-
Modeling how proteins pick their metal partners
A grant to help understand how proteins choose the right metal ion to work properly inside our bodies.
-
Designing new iron-based catalysts for carbonyl-olefin metathesis
A scientist team is designing smarter iron-containing catalysts to enable carbonyl-olefin metathesis in making medicinal compounds.
-
Molecular role of PhLP3 in human sperm production
A science team is studying a protein called PhLP3 to understand how it affects human sperm development and male fertility.
-
How Spanish-speaking Latino children's language environments affect their bilingual development
This study looks at how talking with family and hearing conversations around them helps Spanish-speaking Latino kids learn two languages, and it aims to find the best ways to support their bilingual growth.
-
Exploring how Spanish-speaking Latino children's early language environments affect their bilingual development
This study looks at how the language experiences of Spanish-speaking Latino kids at home help them learn two languages and improve their reading skills, so we can find better ways to support their learning and success in school.
-
Imaging liver cancer metabolism using advanced technology
This study is exploring a new way to take pictures of how the liver works, especially for people with liver cancer, using a safe and non-invasive method that could help doctors better understand and treat liver diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.