Investigating how magnesium stents corrode in inflammatory environments
Deciphering the relationship between bioresorbable magnesium alloy corrosion and the inflammatory microenvironment of the neotinima
['FUNDING_R15'] · MARQUETTE UNIVERSITY · NIH-10992040
This study is looking at how special magnesium stents, which dissolve in the body, react when there's inflammation from heart disease, to help make these stents work better for people with this condition.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MARQUETTE UNIVERSITY (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-10992040 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how bioresorbable magnesium alloy stents behave in the presence of inflammation associated with atherosclerosis. The team will study how the inflammatory microenvironment affects the corrosion of these stents and how the resulting corrosion products may influence the progression of neointimal growth. Using advanced imaging techniques and a mouse model, they will analyze the interaction between inflammatory cells and magnesium alloys to gather insights that could improve stent design and performance.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals with atherosclerosis or those requiring stent implantation for cardiovascular issues.
Not a fit: Patients who do not have atherosclerosis or do not require stent placement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved bioresorbable stents that minimize complications and enhance healing in patients with cardiovascular conditions.
How similar studies have performed: While the use of magnesium alloys in stents is being explored, this specific investigation into their corrosion in inflammatory environments is relatively novel.
Where this research is happening
MILWAUKEE, UNITED STATES
- MARQUETTE UNIVERSITY — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUILLORY, ROGER J. — MARQUETTE UNIVERSITY
- Study coordinator: GUILLORY, ROGER J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.