Investigating how magnesium stents corrode in inflammatory environments
Official title: Deciphering the relationship between bioresorbable magnesium alloy corrosion and the inflammatory microenvironment of the neotinima
Funded at Marquette University · NIH-10992040 · Data updated 2026-11-12
This study is looking at how special magnesium stents, which dissolve in the body, react when there's inflammation from heart disease, to help make these stents work better for people with this condition.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marquette University NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2023 |
| Award (this year) | $294,750 |
| NIH project number | 7R15HL167221-02 |
| Project ID | NIH-10992040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals with atherosclerosis or those requiring stent implantation for cardiovascular issues.
✕Less likely to help
Patients who do not have atherosclerosis or do not require stent placement may not benefit from this research.
What this research studies
This research focuses on understanding how bioresorbable magnesium alloy stents behave in the presence of inflammation associated with atherosclerosis. The team will study how the inflammatory microenvironment affects the corrosion of these stents and how the resulting corrosion products may influence the progression of neointimal growth. Using advanced imaging techniques and a mouse model, they will analyze the interaction between inflammatory cells and magnesium alloys to gather insights that could improve stent design and performance.
Why it matters
Potential benefit: If successful, this research could lead to improved bioresorbable stents that minimize complications and enhance healing in patients with cardiovascular conditions.
How similar studies have gone: While the use of magnesium alloys in stents is being explored, this specific investigation into their corrosion in inflammatory environments is relatively novel.
Where this research is happening
-
Marquette University
Milwaukee, United States Active
Researchers
- Principal investigator: Guillory, Roger J. — Marquette University
- Study coordinator: Guillory, Roger J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.