Investigating how macrophages affect tissue changes in rheumatoid arthritis
Macrophages in human autoimmune tissue pathology
This study is looking at how certain immune cells in the joints of people with rheumatoid arthritis might be causing ongoing inflammation and damage, with the hope of finding new ways to protect your joints from harm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hospital for Special Surgery NIH-funded |
| Lab location | 1 site (New York, UNITED STATES) |
| Project ID | NIH-10832471 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific type of immune cell, called macrophages, in the joint tissue of patients with rheumatoid arthritis (RA). By examining how these macrophages interact with other cells in the joint, the study aims to uncover mechanisms that lead to chronic inflammation and tissue damage. Researchers will use advanced techniques like single-cell RNA sequencing and cell culture models to explore how these immune cells contribute to the disease and how their activity can be inhibited. The goal is to identify potential therapeutic targets that could help prevent joint damage in RA patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with rheumatoid arthritis who are experiencing chronic joint inflammation.
Not a fit: Patients with other types of arthritis or autoimmune conditions unrelated to rheumatoid arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent joint damage and improve the quality of life for patients with rheumatoid arthritis.
How similar studies have performed: Previous studies have shown promising results in understanding macrophage roles in autoimmune diseases, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
New York, UNITED STATES
- Hospital for Special Surgery — New York, United States (Active)
Researchers
- Principal investigator: Donlin, Laura T. — Hospital for Special Surgery
- Study coordinator: Donlin, Laura T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.