Investigating how macrophages adapt their metabolism during endotoxin tolerance
Official title: Dynamic reprogramming of macrophage acetyl-CoA metabolism in endotoxin tolerance
Funded at University of Wisconsin-Madison · NIH-10898321 · Data updated 2026-11-12
This study is looking at how certain immune cells called macrophages change their energy use when they encounter substances that cause inflammation, and it aims to find out how a key molecule, acetyl-CoA, helps these cells adapt to repeated exposure to these substances, which could be important for understanding conditions like sepsis.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 4, 2024 |
| Project end | September 3, 2027 |
| Funding year | 2024 |
| Award (this year) | $39,816 |
| NIH project number | 1F30AI183563-01 |
| Project ID | NIH-10898321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be experiencing conditions related to inflammation or sepsis.
✕Less likely to help
Patients with non-inflammatory conditions or those who are not adults may not receive any benefit from this research.
What this research studies
This research focuses on understanding how macrophages, a type of immune cell, change their metabolism in response to endotoxins, which are substances that can trigger inflammation. The study aims to explore how the availability of a key metabolic molecule, acetyl-CoA, influences the ability of macrophages to become tolerant to repeated endotoxin exposure. By examining the effects of acetyl-CoA on gene expression and protein modifications, the research seeks to uncover the mechanisms behind endotoxin tolerance, which can have significant implications for conditions like sepsis. The research will utilize murine models to simulate these processes and gather data on metabolic changes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing inflammatory responses in patients, particularly those suffering from conditions like sepsis.
How similar studies have gone: While the specific focus on acetyl-CoA metabolism in endotoxin tolerance is novel, similar research has shown promising results in understanding metabolic reprogramming in immune responses.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Arp, Nicholas Lawrence — University of Wisconsin-Madison
- Study coordinator: Arp, Nicholas Lawrence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.