Investigating how M4 receptor activators can reduce repetitive behaviors in certain disorders
Pharmacological modulation of striatal physiology and repetitive behaviors by M4 PAMs
This study is looking at how activating a certain brain receptor might help reduce repetitive behaviors in people with conditions like Autism, OCD, and Tourette’s Syndrome, using animal models to see if this approach can make a positive difference in their daily lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10974037 on NIH RePORTER |
What this research studies
This research focuses on understanding how activating a specific receptor in the brain, known as the M4 muscarinic acetylcholine receptor, can help reduce repetitive behaviors associated with disorders like Autism Spectrum Disorder (ASD), Obsessive-Compulsive Disorder (OCD), and Tourette’s Syndrome. The study aims to explore the role of the striatum, a brain region involved in behavior regulation, and how its neurotransmission can be modulated to alleviate these challenging symptoms. By using animal models, researchers will test the effectiveness of M4 receptor activators in reversing the abnormal behaviors that significantly impact patients' daily lives.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Autism Spectrum Disorder, Obsessive-Compulsive Disorder, or Tourette’s Syndrome who experience significant repetitive behaviors.
Not a fit: Patients without these specific disorders or those who do not exhibit repetitive behaviors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that more effectively reduce repetitive behaviors in patients with ASD and related disorders.
How similar studies have performed: Previous research has shown promise in targeting similar receptors for behavioral modulation, suggesting that this approach could yield beneficial results.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Foster, Daniel J — University of South Carolina at Columbia
- Study coordinator: Foster, Daniel J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.