Investigating how lysosomes communicate with the nucleus to influence aging and lifespan.
TFEB-mediated lysosome-to-nucleus signaling in aging and lifespan regulation
This study is looking at how tiny cell structures called lysosomes help control aging and communicate with the cell's nucleus, with the hope of finding new ways to treat age-related diseases and improve how long and healthy we live.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11051222 on NIH RePORTER |
What this research studies
This research explores the role of lysosomes in aging and how they communicate with the nucleus to regulate lifespan. By examining a specific signaling pathway involving a transcription factor, the study aims to identify cellular and molecular targets that could lead to treatments for age-related diseases. The approach includes using advanced tools to analyze lysosomal content and signaling mechanisms in aging cells. Patients may benefit from insights that could lead to new therapies aimed at improving healthspan and lifespan.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or neurodegenerative conditions.
Not a fit: Patients who are younger and do not have age-related diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance health and longevity in aging populations.
How similar studies have performed: Previous research has shown promising results in extending lifespan through similar cellular signaling pathways, indicating potential for success in this approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Sardiello, Marco — Baylor College of Medicine
- Study coordinator: Sardiello, Marco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.