Investigating how lysosomes communicate with the nucleus in aging and Alzheimer's disease
Lysosome Regulation and Signaling in Aging and Alzheimer's Disease
This study is looking at how tiny cell structures called lysosomes communicate with the cell's control center, the nucleus, to keep our cells healthy as we age and in Alzheimer's disease, hoping to find ways to help clear out harmful proteins and improve health for those affected by these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11200904 on NIH RePORTER |
What this research studies
This research focuses on understanding the signaling pathways between lysosomes and the nucleus that regulate cellular health in aging and Alzheimer's disease. By using advanced imaging techniques and mouse models, the team aims to explore how lysosomal function impacts cellular clearance mechanisms, particularly in conditions related to tau protein accumulation. The research involves in vitro culture systems and requires specialized equipment to visualize these processes effectively. Patients may benefit from insights gained into how to enhance cellular clearance and potentially improve outcomes in Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of Alzheimer's disease or those at risk due to aging.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by Alzheimer's disease may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular health and clearance mechanisms in patients with Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in understanding lysosomal function in neurodegenerative diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Zheng, Hui — Baylor College of Medicine
- Study coordinator: Zheng, Hui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.