Investigating how lymphatic vessels in the brain affect immune communication in young children.
Official title: Role of meningeal lymphatic vasculature in neuroimmune communication development
Funded at Yale University · NIH-11112292 · Data updated 2026-11-12
This study is looking at how tiny vessels in the brain help the immune system talk to the brain during early life, especially in young mice, to learn more about how this communication might affect kids with brain tumors like medulloblastoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $494,067 |
| NIH project number | 5R01NS130057-03 |
| Project ID | NIH-11112292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include young children, particularly those diagnosed with brain tumors or other neuroimmune conditions.
✕Less likely to help
Patients who are adults or do not have conditions related to neuroimmune communication may not benefit from this research.
What this research studies
This research explores the role of developing meningeal lymphatic vessels (MLVs) in the communication between the immune system and the brain during early postnatal life. By studying young mice, the researchers aim to understand how these vessels influence immune responses, particularly in the context of pediatric brain tumors like medulloblastoma. The study employs advanced imaging techniques and molecular analysis to uncover the mechanisms of neuroimmune communication and the potential for enhancing immune responses through specific signaling pathways.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving immune responses in children with brain tumors.
How similar studies have gone: While the specific focus on MLVs in pediatric neuroimmune communication is novel, related research has shown promise in understanding immune responses in other contexts.
Where this research is happening
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Yale University
New Haven, United States Active
Researchers
- Principal investigator: Thomas, Jean-Leon — Yale University
- Study coordinator: Thomas, Jean-Leon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.