Investigating how lung stem cells regenerate and are affected by immune responses after transplantation
Official title: Lung Allograft Stem Cell Regeneration and Immune Destruction
Funded at Research Inst Nationwide Children's Hosp · NIH-11114033 · Data updated 2026-11-12
This study is looking at how losing certain stem cells in the lungs impacts the healing process after a lung transplant, with the goal of finding better treatments for people dealing with lung issues after their transplant.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | June 14, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $248,999 |
| NIH project number | 5R00HL155843-04 |
| Project ID | NIH-11114033 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with end-stage lung disease who are considering or have undergone lung transplantation.
✕Less likely to help
Patients with lung diseases that are not eligible for transplantation or those who do not have chronic lung allograft dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the loss of specific stem cells in the lungs and how this affects the body's ability to regenerate airway tissue after lung transplantation. By using advanced animal models, the study will explore the role of certain cells in the lungs that may contribute to chronic lung allograft dysfunction (CLAD), a condition that affects many lung transplant recipients. The researchers aim to uncover the mechanisms behind these processes, which could lead to improved treatments for patients suffering from end-stage lung disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung regeneration and improve outcomes for lung transplant patients.
How similar studies have gone: Previous research has shown promise in understanding stem cell dynamics in other organ transplants, but this specific approach to lung regeneration is relatively novel.
Where this research is happening
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Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Lynch, Thomas J — Research Inst Nationwide Children's Hosp
- Study coordinator: Lynch, Thomas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.