Investigating how lung stem cells affect breast cancer spread after chemotherapy
The Role of Lung Resident Mesenchymal Stem Cells in Post-Chemotherapy Lung Metastases of Breast Cancer
This study is looking at how certain cells in the lungs might help breast cancer come back after chemotherapy, with the hope of finding better ways to treat the cancer and keep it from returning.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10879389 on NIH RePORTER |
What this research studies
This research explores the role of lung resident mesenchymal stem cells in the recurrence of breast cancer after chemotherapy. It aims to understand how these stem cells, which are part of the lung's tissue environment, may help cancer cells survive and spread following treatment. By examining the interactions between chemotherapy and these stem cells, the study seeks to uncover mechanisms that allow cancer to return, potentially leading to new therapeutic strategies. Patients may benefit from insights that could improve treatment outcomes and reduce the chances of cancer recurrence.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients who have undergone chemotherapy and are at risk of metastasis.
Not a fit: Patients who have not received chemotherapy or those with non-breast cancer diagnoses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies that prevent breast cancer from returning after chemotherapy.
How similar studies have performed: Previous research has shown that understanding the tumor microenvironment can lead to significant advancements in cancer treatment, suggesting this approach has potential for success.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Ren, Guangwen — Jackson Laboratory
- Study coordinator: Ren, Guangwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.