Investigating how lung premalignant lesions behave over time
Official title: Persistence and regression in lung premalignant lesions
Funded at University of Colorado Denver · NIH-11045467 · Data updated 2026-11-12
This study is looking at early changes in the lungs that could lead to cancer, especially in former smokers and lung cancer survivors, to find ways to prevent lung cancer by identifying which changes are more likely to get worse and which might get better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 5, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $566,523 |
| NIH project number | 1R01CA289576-01A1 |
| Project ID | NIH-11045467 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with lung premalignant lesions, particularly former smokers and lung cancer survivors.
✕Less likely to help
Patients without lung premalignant lesions or those with advanced lung cancer may not benefit from this research.
What this research studies
This research focuses on understanding the behavior of lung premalignant lesions (PMLs) to better prevent lung cancer. It aims to identify molecular patterns that distinguish PMLs likely to progress to cancer from those that may regress. By targeting high-risk patients, particularly former smokers and lung cancer survivors, the study seeks to develop precision prevention strategies that could reduce the risk of lung cancer. The approach involves analyzing key mechanisms in persistent PMLs to inform targeted pharmacological interventions.
Why it matters
Potential benefit: If successful, this research could lead to effective prevention strategies that significantly lower the risk of lung cancer in high-risk patients.
How similar studies have gone: Previous research has shown promise in identifying molecular patterns in cancer prevention, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Tennis, Meredith a — University of Colorado Denver
- Study coordinator: Tennis, Meredith a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.