Investigating how lung injury affects brain development in preterm infants
Exosomal Gasdermin D Mediated Lung to Brain Crosstalk in Preterm Brain Injury
This study is looking at how tiny particles from the lungs might affect brain health in premature babies, especially when they have lung problems, to find new ways to help protect their brains from injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10850209 on NIH RePORTER |
What this research studies
This research explores the role of extracellular vesicles (EVs) in the communication between the lungs and the brain, particularly focusing on how these vesicles contribute to brain injury and neurodevelopmental impairment in preterm infants. The study examines the mechanisms by which inflammatory processes, specifically involving gasdermin D, affect brain development following lung complications like bronchopulmonary dysplasia. By analyzing the presence of specific proteins in circulating EVs, the research aims to uncover new therapeutic targets that could mitigate brain injury in this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants who are at risk of developing bronchopulmonary dysplasia and associated neurodevelopmental impairments.
Not a fit: Patients who are full-term infants or those without lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce brain injury in preterm infants suffering from lung complications.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammatory processes in brain injury, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Wu, Shu — University of Miami School of Medicine
- Study coordinator: Wu, Shu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.