Investigating how lung injury affects brain development in preterm infants
Exosomal Gasdermin D Mediated Lung to Brain Crosswalk in Preterm Brain Injury
This study is looking at how lung problems in premature babies, like bronchopulmonary dysplasia, might affect their brain development, and it’s exploring whether tiny particles called exosomes can carry important signals from the lungs to the brain that could help us find new ways to protect these babies' brains.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-10653147 on NIH RePORTER |
What this research studies
This research focuses on understanding the connection between lung injury, specifically bronchopulmonary dysplasia (BPD), and neurodevelopmental impairment in preterm infants. The study examines how exosomes, which are tiny vesicles released from cells, may carry signals from the lungs to the brain that contribute to brain injury. By analyzing these exosomes and the role of a protein called gasdermin D, researchers aim to uncover the mechanisms behind this communication and its impact on brain health. This knowledge could lead to new therapeutic strategies for preventing brain injury in vulnerable infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are preterm infants diagnosed with bronchopulmonary dysplasia.
Not a fit: Patients who are full-term infants or those without any lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for preventing neurodevelopmental issues in preterm infants with lung injury.
How similar studies have performed: Other research has shown promising results in understanding the role of exosomes in various diseases, but this specific approach to linking lung injury and brain development in preterm infants is relatively novel.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Wu, Shu — University of Miami School of Medicine
- Study coordinator: Wu, Shu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.