Investigating how lung infections affect cell signaling and injury repair
Official title: Soluble adenylyl cyclases in lung endothelial tauopathy
Funded at University of South Alabama · NIH-11038029 · Data updated 2026-11-12
This study is looking at how a specific enzyme in the lungs helps respond to infections like those caused by Pseudomonas aeruginosa, which can hurt lung function, and it hopes to find new ways to help people recover better from these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | March 20, 2023 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $433,597 |
| NIH project number | 5R01HL167997-03 |
| Project ID | NIH-11038029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with acute lung injury or those suffering from infections caused by Pseudomonas aeruginosa.
✕Less likely to help
Patients with chronic lung conditions unrelated to acute infections may not benefit from this research.
What this research studies
This research focuses on understanding the role of soluble adenylyl cyclases in the lung's response to infections, particularly from Pseudomonas aeruginosa. It examines how this bacterium disrupts the alveolar-capillary barrier, leading to lung injury and impaired oxygenation. The study looks at the signaling mechanisms involved, specifically how certain enzymes produce cyclic nucleotides that can lead to harmful changes in lung cells. By exploring these pathways, the research aims to uncover potential targets for improving recovery from lung infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung repair and function after bacterial infections.
How similar studies have gone: Previous research has shown promising results in understanding the role of cyclic nucleotides in lung injury, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Stevens, Troy — University of South Alabama
- Study coordinator: Stevens, Troy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.