Investigating how lung immune cells respond to harmful environmental exposures
Official title: Targeting the ACOD1 immunometabolic pathway of lung myeloid cells to reduce environmental exposure-induced lung disease
Funded at University of Nebraska Medical Center · NIH-11014958 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs respond to harmful things we breathe in, with the goal of finding new ways to help people with lung diseases like asthma and COPD feel better and recover faster.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | January 15, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $38,291 |
| NIH project number | 5F30ES036063-02 |
| Project ID | NIH-11014958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with respiratory conditions exacerbated by environmental factors, such as asthma or chronic bronchitis.
✕Less likely to help
Patients with lung diseases not related to environmental exposures may not benefit from this research.
What this research studies
This research focuses on understanding how lung immune cells, particularly myeloid cells, react to harmful substances in the air that can lead to lung diseases. By examining the pathways involved in inflammation caused by these exposures, the study aims to identify potential therapeutic targets that could help reduce lung injury and improve recovery. The research utilizes advanced techniques such as RNA sequencing to analyze the behavior of immune cells in response to environmental stressors. Patients may benefit from insights gained that could lead to new treatments for conditions like asthma and chronic obstructive pulmonary disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the impact of environmental exposures on lung health.
How similar studies have gone: Previous research has shown promise in targeting inflammatory pathways in lung diseases, suggesting that this approach may yield beneficial results.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Schwab, Aaron — University of Nebraska Medical Center
- Study coordinator: Schwab, Aaron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.